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Journal News Thursday, July 29, 2010 \| Source: Circulation: Cardiovascular Interventions Syntax Score Incorporating Clinical Variables Improves PCI Risk Prediction By Jason Kahn Combining the anatomic based Syntax Score with 3 simple clinical variables improves the model’s ability to predict major adverse events and mortality… Wednesday, July 28, 2010 \| Source: Circulation Novel Reversible Anticoagulant Shows Promise in Elective PCI By Kim Dalton A new anticoagulant therapy aimed at inhibition and rapid reversal of the factor IXa pathway is safe and feasible in patients undergoing elective percutaneous… Wednesday, July 28, 2010 \| Source: Circulation: Cardiovascular Quality and Outcomes Direct Transport of STEMI Patients to PCI Hospitals Improves Outcomes, Lowers Costs By Caitlin E. Cox Transporting every patient with ST segment elevation myocardial infarction (STEMI) directly to a percutaneous coronary intervention (PCI) center by… Tuesday, July 27, 2010 \| Source: Archives of Internal Medicine Wide Variations Seen in National Carotid Revascularization Patterns By L.A. McKeown Use of carotid endarterectomy (CEA) and carotid artery stenting (CAS) varies significantly across different parts of the United States, according to… Monday, July 26, 2010 \| Source: Journal of the American College of Cardiology Studies Show Eptifibatide Equivalent to Abciximab During PCI for STEMI By Kim Dalton The small molecule glycoprotein IIb IIIa inhibitor (GPI) eptifibatide is just as safe and effective as the better studied but more expensive abciximab… Monday, July 26, 2010 \| Source: Circulation: Cardiovascular Interventions Meta-analysis: Iodixanol Shows Slight Advantage Over Other Low Osmolar Agents By Jason Kahn The low osmolar contrast agent iodixanol shows a slight, though nonsignificant, ability to protect against contrast induced nephropathy (CIN) compared… Friday, July 23, 2010 \| Source: JACC: Cardiovascular Interventions Genetic Variants Affect Clopidogrel Response Even When Doses Are Increased By L.A. McKeown Increasing the maintenance dose of clopidogrel does not effectively overcome high post treatment platelet reactivity in patients who are carriers of… Friday, July 23, 2010 \| Source: Circulation: Cardiovascular Interventions Novel Biodegradable Stent Does Not Improve Strut Coverage By Caitlin E. Cox A new generation stent with an ultrathin abluminal coating of paclitaxel microdots eluted from a biodegradable polymer does not improve strut coverage… Thursday, July 22, 2010 \| Source: Journal of the American Medical Association Tight BP Control Does Not Help Patients with Diabetes, CAD By Allison Eitman In patients with diabetes and coronary artery disease (CAD), reducing systolic blood pressure to less than 130 mm Hg does not lower cardiovascular… Thursday, July 22, 2010 \| Source: Circulation Percutaneous Pulmonary Valve Demonstrates Encouraging Short-term Results By Jason Kahn A transcatheter pulmonary valve for use in patients with dysfunctional right ventricular outflow tract (RVOT) conduits has shown a high rate of procedural… Wednesday, July 21, 2010 \| Source: JACC: Cardiovascular Interventions Ultrasound Guidance Facilitates Femoral Access, Cuts Complications By Kim Dalton Compared with fluoroscopy, real time ultrasound imaging facilitates catheter insertion and reduces the risk of complications for patients undergoing… Wednesday, July 21, 2010 \| Source: JACC: Cardiovascular Interventions Direct Transport to PCI Center Improves Outcomes in STEMI Patients By Caitlin E. Cox Diagnosing ST segment elevation myocardial infarction (STEMI) in the ambulance and transporting patients directly to a percutaneous coronary… Tuesday, July 20, 2010 \| Source: Archives of Surgery Good Short-term Results for Endovascular Repair of Blunt Aortic Injury By L.A. McKeown Injuries to the thoracic aorta that occur as a result of blunt force trauma can be safely treated via endovascular repair, according to a small study… Monday, July 19, 2010 \| Source: JACC: Cardiovascular Interventions Insurance Status Affects Decision to Use DES By Jason Kahn Among patients undergoing percutaneous coronary intervention (PCI), those with Medicaid or no health insurance are less likely to receive a drug eluting… Monday, July 19, 2010 \| Source: Journal of the American College of Cardiology Short D2B Times Have Greater Mortality Impact on STEMI Early Presenters By Kim Dalton Door to balloon (D2B) times within the recommended guidelines reduce 1 year mortality in patients with ST segment elevation myocardial infarction (STEMI)… Friday, July 16, 2010 \| Source: Circulation: Cardiovascular Interventions Improvements in PCI for Elderly Patients Yield Benefits By Caitlin E. Cox Over a 7 year period beginning in 2000, the elderly made up an increasingly higher proportion of patients undergoing nonemergent percutaneous coronary… Friday, July 16, 2010 \| Source: European Heart Journal CTA Can Detect CAD in Patients with Atrial Fibrillation By Alison Palkhivala Computed tomographic angiography (CTA) can detect coronary artery disease (CAD) in selected patients with atrial fibrillation (A fib), according to… Thursday, July 15, 2010 \| Source: US News and World Report US News: Cleveland Clinic Maintains Rank as No. 1 Heart Hospital By Kim Dalton The Cleveland Clinic once again earned the top ranking for heart care and heart surgery in the US News & World Report annual evaluation of the… Thursday, July 15, 2010 \| Source: Journal of Vascular Surgery Comparison of Carotid Stenting, Endarterectomy Stirs Up More Debate By Jason Kahn A study looking at over 47,000 patients with carotid artery disease in New York and California found that stenting is equivalent to open surgery in… Wednesday, July 14, 2010 \| Source: American Journal of Cardiology Radial Approach Superior vs. Femoral for Primary PCI in STEMI Patients By Caitlin E. Cox Using the radial approach during primary percutaneous coronary intervention (PCI) for ST segment elevation myocardial infarction (STEMI) is associated… Wednesday, July 14, 2010 \| Source: Circulation: Cardiovascular Interventions New Model Predicts DES Restenosis Risk By Kim Dalton A simple score incorporating 6 clinical and angiographic characteristics can help predict the risk of clinically driven restenosis in patients receiving… Tuesday, July 13, 2010 \| Source: Journal of Internal Medicine Severe Angina More Predictive of CAD in Women vs. Men By L.A. McKeown Severe angina appears to be a greater predictor of severe coronary artery disease (CAD) in women than in men, according to a study published in the… Tuesday, July 13, 2010 \| Source: Journal of Vascular and Interventional Radiology Society of Interventional Radiology Issues Global Definition of Specialty By Allison Eitman The Society of Interventional Radiology (SIR) has issued a global statement that defines interventional radiology. The document, published online July… Monday, July 12, 2010 \| Source: Journal of the American College of Cardiology Syntax Score Validated in All-Comers LEADERS Trial By Jason Kahn On the heels of several studies that showed the benefit of alternative models in predicting safety in patients undergoing percutaneous coronary intervention… Monday, July 12, 2010 \| Source: Journal of the American College of Cardiology Better MI Care, Safer PCI Among Trends Identified in National Registries By Kim Dalton The past few years have seen incremental improvement in treatment and outcomes for patients with acute myocardial infarction (AMI). Meanwhile, use… Friday, July 09, 2010 \| Source: Journal of the American College of Cardiology Cardiac Imaging Leads to Substantial Radiation Exposure By L.A. McKeown While the association between radiation exposure from medical tests and increased risk of cancer is debatable, data from a study published online July… Friday, July 09, 2010 \| Source: Circulation: Cardiovascular Interventions Subclavian Access Feasible, Safe with Transcatheter CoreValve Device By Caitlin E. Cox In patients undergoing transcatheter aortic valve implantation (TAVI), subclavian access may be feasible for those with anatomical or disease characteristics… Thursday, July 08, 2010 \| Source: European Heart Journal Early PCI After Fibrinolysis Safely Reduces Reinfarction, Recurrent Ischemia By Heather Lindsey Routine early percutaneous coronary intervention (PCI) following fibrinolysis in patients with ST segment elevation myocardial infarction (STEMI) reduces… Wednesday, July 07, 2010 \| Source: European Heart Journal SES Superior to BMS for Chronic Total Occlusions By Caitlin E. Cox In chronic total occlusions (CTOs), treatment with sirolimus eluting stents (SES) results in less restenosis at 8 months compared with bare metal stents… Tuesday, July 06, 2010 \| Source: Journal of the American College of Cardiology Ticagrelor: Despite Dyspnea Risk, No Evidence of Cardiopulmonary Dysfunction By Kim Dalton Dyspnea is fairly common among patients receiving ticagrelor, but the side effect is typically mild and transient. More important, ticagrelor therapy… view all journal news Conference News Tuesday, June 01, 2010 \| Source: EuroPCR 2010 EuroPCR 2010: Trials Expand Database on Novel Stents, Percutaneous Valves By Kim Dalton PARIS, France—The late breaking trials featured at last week’s EuroPCR 2010 were the winners from among a record 70 plus submissions. Several offered… Friday, May 28, 2010 \| Source: EuroPCR 2010 Repeated Clopidogrel Loading Doses Can Improve Platelet Response By Caitlin E. Cox PARIS, France—In patients who are carriers of the CYP2C19 2 loss of function allele, progressively increasing the clopidogrel loading dose may help… Friday, May 28, 2010 \| Source: EuroPCR 2010 Transcatheter Aortic Valve Procedures Lead to New, Albeit Silent, Cerebral Lesions By Caitlin E. Cox PARIS, France—Transcatheter aortic valve implantation (TAVI) is associated with a high rate of new silent cerebral ischemic lesions, regardless of… Friday, May 28, 2010 \| Source: EuroPCR 2010 Stent Fracture, Strut Malapposition Common in Stent Thrombosis Cases By Jason Kahn PARIS, France—In patients undergoing percutaneous coronary intervention (PCI) who experience stent thrombosis, stent fracture and strut malapposition… Friday, May 28, 2010 \| Source: EuroPCR 2010 Intracoronary Adenosine Reduces Myonecrosis in Elective PCI Patients By Jason Kahn PARIS, France—In patients who are not given or do not respond to clopidogrel before elective percutaneous coronary intervention (PCI), intracoronary… Thursday, May 27, 2010 \| Source: EuroPCR 2010 First Year of Data Show Promising Survival With Transcatheter Aortic Valve By Jason Kahn PARIS, France—The first full year of experience with a transcatheter aortic valve implantation (TAVI) in over 1,000 patients, many of them not eligible… Thursday, May 27, 2010 \| Source: EuroPCR 2010 Left Transradial Approach Superior to Right-Side Access By Caitlin E. Cox PARIS, France—When performing cardiac catheterization via the transradial approach, accessing through the left radial artery slightly lowers fluoroscopy… Thursday, May 27, 2010 \| Source: EuroPCR 2010 New Stent Designs Show Mixed Results Versus Endeavor By Jason Kahn PARIS, France—Two new stents, one with a “passive” coating to reduce inflammation, the other a drug eluting stent (DES) that releases a sirolimus analog,… Thursday, May 27, 2010 \| Source: EuroPCR 2010 Positive Signs for Biolimus A9-Eluting Stents By Caitlin E. Cox PARIS, France—Late breaking trials presented May 25 at EuroPCR 2010 provided good news about real world use of 2 different biolimus A9 eluting stents… Wednesday, May 26, 2010 \| Source: EuroPCR New DES Design Holds Its Own With Taxus Through 1 Year By Caitlin E. Cox PARIS, France—Twelve month results for a new sirolimus eluting stent featuring micro reservoirs and a biodegradable polymer show promising clinical… Wednesday, May 26, 2010 \| Source: EuroPCR 2010 Drug-Eluting Balloon Disappoints in Bifurcation Lesions By Jason Kahn PARIS, France—In the latest setback for an intriguing technology, a paclitaxel eluting balloon combined with a bare metal stent (BMS) failed to improve… Wednesday, May 26, 2010 \| Source: EuroPCR 2010 Xience V Effective in Diabetics, With Low Stent Thrombosis in Real World Patients By Jason Kahn PARIS, France—Everolimus eluting stents are angiographically superior to paclitaxel eluting stents in diabetic subjects. Moreover, they are associated… Wednesday, May 26, 2010 \| Source: EuroPCR 2010 JETSTENT: Thrombectomy Continues to Improve Clinical Outcomes at 1 Year By Caitlin E. Cox PARIS, France—Mechanical thrombectomy added to direct stenting in patients experiencing ST segment elevation myocardial infarction (STEMI) improves… Tuesday, May 25, 2010 \| Source: EuroPCR 2010 Resolute Zotarolimus-Eluting Stent Noninferior to Xience V By Caitlin E. Cox PARIS, France—A novel zotarolimus eluting stent (ZES) shows equivalent safety and effectiveness compared with an everolimus eluting stent (EES) already… Tuesday, May 25, 2010 \| Source: EuroPCR 2010 Clip Device Effective for Both Functional, Degenerative Mitral Regurgitation By Jason Kahn PARIS, France—Mitral valve repair with a percutaneously delivered clip treats mitral regurgitation (MR) effectively whether the condition is degenerative… Friday, May 07, 2010 \| Source: Society for Cardiovascular Angiography and Interventions 2010 Zilver Stent Shows High Event-Free Survival at 2 Years in Patients with PAD By L.A. McKeown Interim results from a global registry show that stenting of superficial femoropopliteal artery (SFA) lesions with polymer free paclitaxel eluting… Wednesday, May 05, 2010 \| Source: Society of Cardiovascular Angiography and Interventions (SCAI) Scientific Sessions 2010 Radial Access: Despite Steep Learning Curve, Patients Go Home Earlier By Caitlin E. Cox Radial access intervention presents a surprisingly steep learning curve at teaching hospitals newly undertaking the approach, according to research… Monday, March 22, 2010 \| Source: American College of Cardiology/I2 Summit 2010 ACC-i2 Summit 2010: New Data Answer Some Questions, Raise Others By Kim Dalton ATLANTA, GA—The American College of Cardiology 59th Annual Scientific Session i2 Summit held last week from March 14 to 16, 2010, featured late breaking… Friday, March 19, 2010 \| Source: Society of Interventional Radiology Annual Scientific Meeting Proximal Cerebral Protection Device Increases Safety of Carotid Stenting By L.A. McKeown Use of a proximal cerebral protection device during carotid artery stenting achieves a significantly reduced risk of stroke, death, and myocardial… Tuesday, March 16, 2010 \| Source: American College of Cardiology/I2 Summit 2010 Trials Look at Which Migraine Sufferers May Benefit from PFO Closure By Jason Kahn ATLANTA, GA—Two long term, prospective studies add valuable pieces to the puzzle that has confounded neurologists and cardiologists for the past several… Tuesday, March 16, 2010 \| Source: American College of Cardiology/I2 Summit 2010 Percutaneous LAA Closure Device Continues to Perform Well By Kim Dalton ATLANTA, GA—Intermediate term data show that closure of the left atrial appendage (LAA) with a catheter delivered device continues to provide a safe… Tuesday, March 16, 2010 \| Source: American College of Cardiology/I2 Summit 2010 Long-Term Data on DES Use in STEMI Patients Raise Concerns By Jason Kahn ATLANTA, GA—Long term follow up from 2 randomized trials sheds light on the risk of late events with drug eluting stents (DES) in patients with ST… Tuesday, March 16, 2010 \| Source: American College of Cardiology/I2 Summit 2010 Ticagrelor Safer for ACS Patients Who May Need Urgent CABG By Kim Dalton ATLANTA, GA—Among patients with acute coronary syndromes (ACS) who undergo coronary artery bypass grafting (CABG) within 7 days of stopping antiplatelet… Tuesday, March 16, 2010 \| Source: Source: American College of Cardiology/I2 Summit 2010 Thrombectomy Improves Myocardial Reperfusion, Clinical Outcomes in STEMI By Caitlin E. Cox ATLANTA, GA—Thrombectomy given in addition to direct stenting in patients experiencing ST segment elevation myocardial infarction (STEMI) produces… Tuesday, March 16, 2010 \| Source: American College of Cardiology/I2 Summit 2010 Genotyping Associated with Fewer Hospitalizations in Warfarin Patients By Caitlin E. Cox ATLANTA, GA—Testing for genetic variants that affect response to warfarin allows physicians to fine tune dosing of the drug for their patients. Genotyping… Monday, March 15, 2010 \| Source: American College of Cardiology/I2 Summit 2010 Studies Compare Multiple Drug-Eluting Stents By Caitlin E. Cox ATLANTA, GA—Two late breaking clinical trials presented Monday, March 15, 2010, at the ACC i2 Summit show mixed results for Endeavor when tested against… Monday, March 15, 2010 \| Source: American College of Cardiology/I2 Summit 2010 Cilostazol Improves Platelet Reactivity, Not Clinical Outcomes in DES Patients By Jason Kahn ATLANTA, GA—Triple antiplatelet therapy with cilostazol added to clopidogrel and aspirin lowers platelet reactivity compared with standard dual therapy… Monday, March 15, 2010 \| Source: American College of Cardiology/I2 Summit 2010 Meta-analysis: Routine Invasive Strategy Holds Long-Term Advantage for ACS By Kim Dalton ATLANTA, GA—For patients with non ST elevation acute coronary syndromes (NSTE ACS), following a routine invasive strategy reduces the long term relative… Monday, March 15, 2010 \| Source: American College of Cardiology/I2 Summit 2010 STOP-AF: Cryoballoon Ablation Curbs Drug-Refractory A-Fib By Caitlin E. Cox ATLANTA, GA—Cryoballoon ablation effectively treats recurrent drug refractory paroxysmal atrial fibrillation (A fib) in symptomatic patients, according… Monday, March 15, 2010 \| Source: American College of Cardiology/I2 Summit 2010 Sodium Bicarbonate No Help in Preventing CIN in Diabetics By Jason Kahn ATLANTA, GA—Despite recent reports supporting sodium bicarbonate’s ability to protect against contrast induced nephropathy (CIN), results of a new… view all conference news