Routine early percutaneous coronary intervention (PCI) following fibrinolysis in patients with ST-segment elevation myocardial infarction (STEMI) reduces reinfarction and recurrent ischemia at 30 days compared to the standard, more selective approach without increasing stroke or bleeding risk, according to a meta-analysis published online July 2, 2010, ahead of print in the European Heart Journal. However, no difference was seen in 30-day mortality.

Carlo Di Mario, MD, PhD, of the Royal Brompton Hospital (London, United Kingdom), and colleagues analyzed 7 trials of 2,961 patients receiving either PCI within 24 hours after successful fibrinolysis or the conventional approach of limiting PCI to patients ....

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