Company to have strong presence at TCT 2013 with new iFR/FFR data from ADVISE II and analysis of IVUS use in ADAPT-DES featured in scientific program

SAN DIEGO, CA -- Volcano Corporation, a leading developer and manufacturer of precision guided tools designed to enhance the diagnosis and treatment of coronary and peripheral vascular disease, today announced several significant clinical data presentations and other activities related to its physiology and Intravascular Ultrasound (IVUS) technologies at the 25th Annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, being held in San Francisco from October 27 to November 1.

The data include final results from the ADVISE II (ADenosine Vasodilator Independent Stenosis Evaluation) Registry, which will be presented in a Late-Breaking Clinical Trials session on October 30. The prospective, 40-center, global registry evaluated the diagnostic utility of a combined instant wave-Free Ratio™ (iFR^®)¹ and Fractional Flow Reserve (FFR) workflow to reduce the need for hyperemic agents in patients with intermediate or unclear lesions. Additionally, a first look at two-year outcomes from an analysis of use of IVUS in the ADAPT-DES Study, the largest prospective registry of IVUS use to date, will be presented in an oral session. This registry of more than 8,000 patients evaluated the use of IVUS in placing the current generation of drug-eluting stents and its ability to reduce stent thrombosis and impact other clinical outcomes. 

"FFR, iFR and IVUS are technologies that we believe can improve both appropriateness and quality in the diagnosis and treatment of coronary and peripheral vascular disease. However, they are not used as often as they could be," said Scott Huennekens, president and chief executive officer of Volcano Corp. "The new data being presented at TCT 2013 reflect the evolution of our significant investment in clinical science over the last several years, and will help guide physicians in making important patient care decisions. With the approval of our iFR modality in Europe and Japan and the U.S. launch of the new Verrata™ Pressure Guide Wire, our goal is to further simplify workflows so that these advanced technologies become a faster, simpler and more routine part of everyday practice and can benefit more patients."

Volcano will display its products and technologies at Booth 1104, Exhibit H., including three new launches:

• Verrata™ Pressure Guide Wire,
• Crux^® Vena Cava Filter, and
•  iFR^® modality (CE Mark countries and Japan only).

The company will also host a Breakfast Symposium that will showcase data from ADVISE II and the ADAPT-DES IVUS analysis, and review the upcoming SYNTAX II study. Specific details follow.

Key Presentations in the Scientific Program

Tuesday, October 29, 1:15 p.m.
Does IVUS Reduce Stent Thrombosis with DES? Two-Year Results from the Prospective, Multicenter ADAPT-DES Study
Presented by Akiko Maehara, M.D.
Moscone West, 2nd Floor, Room 2010

Wednesday, October 30, 1:54 - 2:06 p.m. 
A Prospective, Registry Evaluation of iFR vs. FFR: ADVISE II*
Presented by Javier Escaned, M.D., Ph.D.
Moscone North, Lower Level, Hall D, Coronary Theater
*First Report Investigation

Volcano-Sponsored Breakfast Symposium

Putting Appropriateness Within Reach: New Global Clinical Data and Workflows
Thursday, October 31
The Moscone Center, Moscone North, Lower Level, Room 132

7:00 a.m.
State of the Union on Global PCI Guidelines Today and Where to Expand in the Future
Manesh Patel, M.D.

7:10 a.m.
New and Future Instant Wave-Free Ratio™ (iFR^®) and IVUS data: ADVISE II and SYNTAX II
Javier Escaned, M.D., Ph.D.

7:20 a.m.
ADAPT-DES: Two-Year Insights from the Largest IVUS Substudy Ever
Bernard Witzenbichler, M.D.

7:30 a.m. 
A More Functional Future: Moving Physiology From Justifying to Deciding Treatment
Justin Davies, M.D., Ph.D.

7:40 a.m.
Functional PCI: An Efficient Workflow for Today and Tomorrow
Bruce Samuels, M.D.

7:50 a.m.
Closing Remarks
Manesh Patel, M.D.

Source: Volcano Corporation