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Presentation TCT 2016

Accounting for the Risk of Competing Events

Presenter: Scott Berry, Stuart J. Pocock, Peter Juni

October 30, 2016

Presentation TCT 2016

Analyzing Repeat Events

Presenter: Scott Berry, Stuart J. Pocock, Eugene H. Blackstone

October 30, 2016

Presentation TCT 2016

Limitations of Composite Endpoints and Strategies for Hierarchical Testing

Presenter: Scott Berry, Stuart J. Pocock, Jan G. P. Tijssen

October 30, 2016

Presentation TCT 2016

Strengths and Limitations of Meta-analysis: Standard, Network and Bayesian Techniques, and the Value of Individual Patient-level Data Pooling

Presenter: Ori Ben-Yehuda, Tullio Palmerini, Giuseppe Biondi-Zoccai

October 30, 2016

Presentation TCT 2016

When Are Randomized Trials Not Enough, and Can Observational Data Reliably Inform Comparative Effectiveness Decisions?

Presenter: Eugene H. Blackstone, Robert W. Yeh, Robert A. Harrington

October 30, 2016

Presentation TCT 2016

Can Propensity and Instrumental Variable Methods Overcome the Limitations of Observational Databases: Lessons From TRANSLATE-ACS

Presenter: Eugene H. Blackstone, Robert W. Yeh, Tracy Y. Wang

October 30, 2016

Presentation TCT 2016

Comparison of Propensity Score Methods and Covariate Adjustment in Observational Studies: Similarities and Differences

Presenter: Eugene H. Blackstone, Robert W. Yeh, Stuart J. Pocock

October 30, 2016

Presentation TCT 2016

Importance of Unmeasured Confounders in Observational Registries: ASCERT and Other Examples

Presenter: Eugene H. Blackstone, Robert W. Yeh, Kirk N. Garratt

October 30, 2016

Presentation TCT 2016

Value and Hazards of Subgroup Analysis: the SYNTAX to EXCEL Case Study

Presenter: Peter Juni, E. Magnus Ohman, Ori Ben-Yehuda

October 30, 2016

Presentation TCT 2016

Clinical Trial Interpretation: Relative vs Absolute Differences

Presenter: Peter Juni, E. Magnus Ohman, John A. Bittl

October 30, 2016

Presentation TCT 2016

Levels of Evidence: Single-center vs Multicenter Trials

Presenter: Peter Juni, E. Magnus Ohman, Roxana Mehran

October 30, 2016

Presentation TCT 2016

Should Clinical Trial Interpretation Be Dominated by A P Value of 0.05 for the Primary Endpoint?

Presenter: Peter Juni, E. Magnus Ohman, Gregg W. Stone

October 30, 2016

Presentation TCT 2016

The Extraordinary Frustration of Converting Meaningful Clinical Trial Results (and Guidelines) Into Changes in Clinical Practice

Presenter: Roxana Mehran, Pascal Vranckx

October 30, 2016

Presentation TCT 2016

Quality-of-Life Measures as Valid Clinical Surrogates and Primary Endpoints in Randomized Trials: Why the Resistance?

Presenter: Roxana Mehran, Pascal Vranckx, John A. Spertus

October 30, 2016

Presentation TCT 2016

Issues With Non-inferiority Trials: Choosing the Margin and Comparator; Creep, Noise, and More

Presenter: Roxana Mehran, Pascal Vranckx, Sanjay Kaul

October 30, 2016

Presentation TCT 2016

Debate: What Is the Optimal Study Design for Maximizing Trial Efficiency, Success, and Interpretability? Adaptive Design in A Bayesian Framework!

Presenter: Roxana Mehran, Pascal Vranckx, Scott Berry

October 30, 2016

Presentation TCT 2016

Debate: What Is the Optimal Study Design for Maximizing Trial Efficiency, Success, and Interpretability? Adaptive Design in a Frequentist Framework!

Presenter: Roxana Mehran, Pascal Vranckx, Stuart J. Pocock

October 30, 2016

Presentation TCT 2016

How to Be a Key Investigator? Its Not Just Quantity- Quality Is Top Priority

Presenter: David A. Cox, Thomas D. Stuckey

October 30, 2016

Presentation TCT 2016

Choice of Primary (or Co-primary) Endpoints: Efficacy, Safety, or Net Clinical Benefit in Superiority and Non-inferiority Trials

Presenter: Roxana Mehran, Pascal Vranckx, Robert A. Harrington

October 30, 2016

Presentation TCT 2016

Quality and Compliance in Research: The Crucial First Step

Presenter: David A. Cox, Thomas D. Stuckey, Kate Dalton

October 30, 2016

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Accounting for the Risk of Competing Events

Analyzing Repeat Events

Limitations of Composite Endpoints and Strategies for Hierarchical Testing

Strengths and Limitations of Meta-analysis: Standard, Network and Bayesian Techniques, and the Value of Individual Patient-level Data Pooling

When Are Randomized Trials Not Enough, and Can Observational Data Reliably Inform Comparative Effectiveness Decisions?

Can Propensity and Instrumental Variable Methods Overcome the Limitations of Observational Databases: Lessons From TRANSLATE-ACS

Comparison of Propensity Score Methods and Covariate Adjustment in Observational Studies: Similarities and Differences

Importance of Unmeasured Confounders in Observational Registries: ASCERT and Other Examples

Value and Hazards of Subgroup Analysis: the SYNTAX to EXCEL Case Study

Clinical Trial Interpretation: Relative vs Absolute Differences

Levels of Evidence: Single-center vs Multicenter Trials

Should Clinical Trial Interpretation Be Dominated by A P Value of 0.05 for the Primary Endpoint?

The Extraordinary Frustration of Converting Meaningful Clinical Trial Results (and Guidelines) Into Changes in Clinical Practice

Quality-of-Life Measures as Valid Clinical Surrogates and Primary Endpoints in Randomized Trials: Why the Resistance?

Issues With Non-inferiority Trials: Choosing the Margin and Comparator; Creep, Noise, and More

Debate: What Is the Optimal Study Design for Maximizing Trial Efficiency, Success, and Interpretability? Adaptive Design in A Bayesian Framework!

Debate: What Is the Optimal Study Design for Maximizing Trial Efficiency, Success, and Interpretability? Adaptive Design in a Frequentist Framework!

How to Be a Key Investigator? Its Not Just Quantity- Quality Is Top Priority

Choice of Primary (or Co-primary) Endpoints: Efficacy, Safety, or Net Clinical Benefit in Superiority and Non-inferiority Trials

Quality and Compliance in Research: The Crucial First Step

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