TCTMD’s Top 10 Most Popular Stories for November 2023
Most of our most-read articles on TCTMD this month stemmed from AHA 2023, with a few important outliers.
All but three of our top 10 stories this month stemmed from the American Heart Association (AHA) 2023 meeting in Philadelphia, with the ORBITA-2 trial topping the list. A breadth of subspecialties are reflected among the other most popular, ranging from acute MI care to cardiometabolic disease and prevention. Rounding out the list are the US Food and Drug Administration’s approval of renal denervation, the stopping of the OCEANIC-AF trial of the factor IXa inhibitor asundexian for stroke prevention, and a PCR London Valves session cautioning against direct comparisons between the recent trials of low-risk TAVI versus SAVR.
In patients not taking antianginal meds, PCI clearly alleviated some—but not all—symptoms. What does that mean in practice?
The trial had to switch out its hard primary endpoints for a win-ratio analysis: the result was a “soft positive,” one observer said.
Obesity specialists and cardiologists hailed the results as a turning point with the potential for a “huge population impact.”
The primary endpoint was missed in MINT, but most study findings suggest a restrictive transfusion strategy has little to add.
This marks the culmination of more than a decade of work, but there are still questions about where the field goes from here.
With an increase in major bleeding, too, there’s a question about whether the benefit is worth the risk.
Stroke was an exploratory endpoint and with few of those events, the PI says it’s impossible to draw any strong conclusions.
Bayer says the phase III trial was stopped early because the novel Factor XIa inhibitor was inferior to apixaban for stroke risk.
9. PCR London Valves Looking for a Winner Between Long-term TAVI Trials? Don’t, Experts Urge
Directly comparing PARTNER 3 and Evolut Low Risk results is like “discussing reincarnation,” one prominent statistician warns.
Lowering LDL is still key, says Paul Ridker, but a new analysis of CLEAR Outcomes is another reminder that hs-CRP also matters.
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