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Presentation TCT 2025

Estimands: Clarifying What We’re Measuring in Clinical Trials

Presenter: Roseann M. White

October 27, 2025

Presentation TCT 2025

Pragmatic, Adapted, and Augmented Trials: Ready for Regulatory Approval

Presenter: Sreekanth Vemulapalli

October 27, 2025

Presentation TCT 2025

Current Trials to Extend LAAC Clinical Indications

Presenter: Shephal K. Doshi

October 27, 2025

Presentation TCT 2025

Joint Modelling for Death and Quality of Life: Worthy as a Primary Endpoint

Presenter: John A. Spertus

October 27, 2025

Presentation TCT 2025

Placebo-Controlled Interventional Trials: A Sham No More

Presenter: Rasha Al-Lamee

October 27, 2025

Presentation TCT 2025

TCT 919: Representation of Resuscitated Out of Hospital Cardiac Arrest Patients in Landmark Cardiogenic Shock Clinical Trials - a Simulated Cohort Study

Presenter: Hugh Lurcott

October 27, 2025

Presentation TCT 2025

Spoiler Alert: Crossovers (Treatment Switches) can Negate the Trial Efficacy: Insights from The Ischemia Trial

Presenter: John Gregson

October 27, 2025

Presentation TCT 2025

The Core of Clinical Event Adjudication: Where is CEC Now and Where Do They Go Next?

Presenter: Marc P. Bonaca

October 27, 2025

Presentation TCT 2025

Percutaneous Coronary Angioplasty Versus Coronary Artery Bypass Grafting in the Treatment of Unprotected Left Main Stenosis: 10-year Mortality Outcomes from the Randomized NOBLE Trial

Presenter: Evald H. Christiansen

October 27, 2025

Presentation TCT 2025

Drug-Coated Balloon Angioplasty with Rescue Stenting Versus Intended Stenting for the Treatment of DeNovo Coronary Artery Lesions: 3-Year Clinical Outcomes of the REC-CAGEFREE I Trial

Presenter: Chao Gao

October 27, 2025

Presentation TCT 2025

TCT 447: Invisible Hearts: The Underrepresentation of Women in Cardiovascular Clinical Trials

Presenter: Pablo Juan Salvadores

October 27, 2025

Presentation TCT 2025

Sirolimus-Eluting Iron Bioresorbable Scaffold in Coronary Artery Disease: Two-Year Results of IRONMAN-II Randomized Controlled Trial

Presenter: Lei Song

October 27, 2025

Presentation TCT 2025

Modifying the Win Ratio for Noninferiority Trials: A Bridge Too Far?

Presenter: Björn Redfors

October 27, 2025

Presentation TCT 2025

Comparison of Drug-Coated Versus Conventional Balloons for Treatment of Side Branches of Bifurcation Lesions: The OCVC-BIF Study

Presenter: Takayuki Ishihara

October 27, 2025

Presentation TCT 2025

Long Term Clinical Outcomes in Patients Treated with the Bioadaptor Compared with a Contemporary Drug Eluting Stent: The INFINITY-SWEDEHEART Randomized Trial

Presenter: David Erlinge

October 27, 2025

Presentation TCT 2025

Regulating with Purpose: The Role of the IRB in the Age of AI

Presenter: R. Scott Wright

October 27, 2025

Presentation TCT 2025

Transforming Clinical Trial Execution Using AI-Based Digital Tools (LearUp)

Presenter: Carlos Granada

October 27, 2025

Presentation TCT 2025

AI-Driven Recruitment: Precision Matching from EHRs to Trials

Presenter: Ryan Ahern

October 27, 2025

Presentation TCT 2025

Smarter Trial Design: Using AI and Real-World Data for Protocol Modeling and Trial Feasibility

Presenter: Harun Kundi

October 27, 2025

Presentation TCT 2025

Commentary

Presenter: Michael J. Reardon

October 27, 2025

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Estimands: Clarifying What We’re Measuring in Clinical Trials

Pragmatic, Adapted, and Augmented Trials: Ready for Regulatory Approval

Current Trials to Extend LAAC Clinical Indications

Joint Modelling for Death and Quality of Life: Worthy as a Primary Endpoint

Placebo-Controlled Interventional Trials: A Sham No More

TCT 919: Representation of Resuscitated Out of Hospital Cardiac Arrest Patients in Landmark Cardiogenic Shock Clinical Trials - a Simulated Cohort Study

Spoiler Alert: Crossovers (Treatment Switches) can Negate the Trial Efficacy: Insights from The Ischemia Trial

The Core of Clinical Event Adjudication: Where is CEC Now and Where Do They Go Next?

Percutaneous Coronary Angioplasty Versus Coronary Artery Bypass Grafting in the Treatment of Unprotected Left Main Stenosis: 10-year Mortality Outcomes from the Randomized NOBLE Trial

Drug-Coated Balloon Angioplasty with Rescue Stenting Versus Intended Stenting for the Treatment of DeNovo Coronary Artery Lesions: 3-Year Clinical Outcomes of the REC-CAGEFREE I Trial

TCT 447: Invisible Hearts: The Underrepresentation of Women in Cardiovascular Clinical Trials

Sirolimus-Eluting Iron Bioresorbable Scaffold in Coronary Artery Disease: Two-Year Results of IRONMAN-II Randomized Controlled Trial

Modifying the Win Ratio for Noninferiority Trials: A Bridge Too Far?

Comparison of Drug-Coated Versus Conventional Balloons for Treatment of Side Branches of Bifurcation Lesions: The OCVC-BIF Study

Long Term Clinical Outcomes in Patients Treated with the Bioadaptor Compared with a Contemporary Drug Eluting Stent: The INFINITY-SWEDEHEART Randomized Trial

Regulating with Purpose: The Role of the IRB in the Age of AI

Transforming Clinical Trial Execution Using AI-Based Digital Tools (LearUp)

AI-Driven Recruitment: Precision Matching from EHRs to Trials

Smarter Trial Design: Using AI and Real-World Data for Protocol Modeling and Trial Feasibility

Commentary

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